SLC25A3

Across TCGA pan-cancer cohorts, SLC25A3 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SLC25A3 data layer compared with 21 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher SLC25A3 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SLC25A3 expression acts as an unfavorable survival marker, although some lineages such as LSCC and GBM show a favorable association.

PDAC, LSCC, and CCRCC are the cancer types where SLC25A3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Tertile	II,III,IV	0.774	0.968	.009	28	view →
LSCC	OS	Median	All	1.000	0.937	.011	9	view →
CCRCC	DFS	Quartile	II,III,IV	0.330	0.765	.031	6	view →
UCEC	DFS	Tertile	All	0.762	0.969	.009	4	view →
GBM	DFS	Tertile	All	0.856	0.645	.023	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SLC25A3–PDAC (OS)

Open the PDAC breakdown →