SLC25A3

Across TCGA patient cohorts, SLC25A3 mutation is significantly associated with the RNA expression of many other genes, with 1,390 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC25A3-associated genes across cancer lineages are IGHD3-16, TRDV3, and RN7SKP134. Each is linked with SLC25A3 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC25A3-to-partner and partner-to-SLC25A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGHD3-16 grouped by SLC25A3-low versus SLC25A3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC25A3→partner) and Y-score (partner→SLC25A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGHD3-16 →	+0.957	+1.925	<.001	<.001	3	3
COAD	TRDV3 →	+0.425	+3.178	.003	.003	3	2
KIRP	RN7SKP134 →	+0.253	+5.645	<.001	<.001	3	2
KIRP	PTP4A1P3 →	+0.217	+5.381	<.001	<.001	3	2
KIRP	RN7SL430P →	+0.297	+4.506	<.001	.005	3	2
UCEC	JAKMIP1 →	+0.570	+1.958	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,390 associations by consensus.

IGHD3-16 by SLC25A3 expression — UCEC

Explore this box plot interactively →