SLC25A3

Across TCGA patient cohorts, SLC25A3 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC25A3-associated genes across cancer lineages are EGFR_pY1068, EGFR, and eIF4E. Each is linked with SLC25A3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC25A3-to-partner and partner-to-SLC25A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by SLC25A3-low versus SLC25A3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC25A3→partner) and Y-score (partner→SLC25A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.219	-2.415	.007	.002	3	1
UCEC	EGFR →	-0.132	-2.295	.010	.033	3	1
UCEC	eIF4E →	+0.178	+2.013	.009	.016	3	1
UCEC	ERK2 →	+0.158	+2.169	.011	.003	3	1
UCEC	JNK_pT183_Y185 →	-0.179	-2.662	.001	<.001	3	1
UCEC	MEK1 →	+0.349	+2.169	.003	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

EGFR_pY1068 by SLC25A3 expression — UCEC

Explore this box plot interactively →