SLC25A3

Across TCGA cell cohorts, SLC25A3 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,486 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible SLC25A3-associated GO terms across cancer lineages are Endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), Endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), and rRNA 5'-end processing. Each is linked with SLC25A3 in more than 11 cancer types. Because this analysis shows association rather than direction, both SLC25A3-to-partner and partner-to-SLC25A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) grouped by SLC25A3-low versus SLC25A3-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC25A3→partner) and Y-score (partner→SLC25A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.093	+0.516	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.081	+0.523	.002	<.001	3	10
OVARY	rRNA 5'-end processing →	+0.109	+0.609	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	Ketone metabolic process →	+0.070	+0.471	.001	.009	3	9
UPPER_AERODIGESTIVE_TRACT	Protein import into mitochondrial intermembrane space →	+0.128	+0.605	.001	.001	3	9
OVARY	Endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.109	+0.609	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,486 associations by consensus.

Endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) by SLC25A3 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →