SLC25A3

Across TCGA cell cohorts, SLC25A3 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC25A3-associated genes across cancer lineages are OR1L6, OR2J2, and TECRL. Each is linked with SLC25A3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC25A3-to-partner and partner-to-SLC25A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1L6 grouped by SLC25A3-low versus SLC25A3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC25A3→partner) and Y-score (partner→SLC25A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR1L6 →	+0.018	+4.022	<.001	.006	3	1
LARGE_INTESTINE	OR2J2 →	+0.016	+3.632	<.001	.003	3	1
LARGE_INTESTINE	TECRL →	+0.014	+3.977	<.001	.001	3	1
LARGE_INTESTINE	OR5V1 →	+0.006	+4.022	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

OR1L6 by SLC25A3 expression — LARGE_INTESTINE

Explore this box plot interactively →