SLC25A3

Across TCGA cell cohorts, SLC25A3 mutation is significantly associated with the mutation status of many other genes, with 2,547 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC25A3-associated genes across cancer lineages are CCSER2, LOXL3, and DEPDC5. Each is linked with SLC25A3 in more than 3 cancer types. Because this analysis shows association rather than direction, both SLC25A3-to-partner and partner-to-SLC25A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCSER2 grouped by SLC25A3-low versus SLC25A3-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC25A3→partner) and Y-score (partner→SLC25A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CCSER2 →	+4.429	+5.247	.005	.005	1	4
BLOOD_Lymphoma	LOXL3 →	+4.014	+4.969	.008	.008	1	4
BLOOD_Lymphoma	DEPDC5 →	+5.014	+5.584	.003	.003	1	3
BLOOD_Lymphoma	KCNQ4 →	+5.014	+5.584	.003	.003	1	3
BLOOD_Leukemia	SCN2A →	+2.672	+4.225	.008	.008	1	3
BLOOD_Lymphoma	FLI1 →	+6.014	+6.014	.001	.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,547 associations by consensus.

CCSER2 by SLC25A3 expression — BLOOD_Lymphoma

Explore this box plot interactively →