SLC25A28

Across TCGA pan-cancer cohorts, SLC25A28 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SLC25A28 data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher SLC25A28 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SLC25A28 expression acts as an unfavorable survival marker, although some lineages such as LSCC and HNSC show a favorable association.

CCRCC, LSCC, and HNSC are the cancer types where SLC25A28 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	All	0.759	0.910	.013	8	view →
LSCC	DFS	Median	II,III,IV	1.000	0.843	.005	8	view →
HNSC	OS	Tertile	IV	0.979	0.629	.013	5	view →
GBM	DFS	Quartile	All	0.719	0.247	.001	5	view →
PDAC	DFS	Median	III,IV	0.361	0.984	.024	3	view →
LUAD	OS	Quartile	III,IV	0.801	0.313	.040	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

SLC25A28–CCRCC (OS)

Open the CCRCC breakdown →