SLC25A28

Across TCGA patient cohorts, SLC25A28 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC25A28-associated genes across cancer lineages are EGFR_pY1068, MSH6, and PDCD4. Each is linked with SLC25A28 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC25A28-to-partner and partner-to-SLC25A28 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by SLC25A28-low versus SLC25A28-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC25A28→partner) and Y-score (partner→SLC25A28) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.260	-2.584	.026	.011	3	1
UCEC	MSH6 →	-0.354	-2.990	.021	.036	3	1
UCEC	PDCD4 →	-0.757	-2.999	<.001	.035	3	1
UCEC	Shc_pY317 →	-0.156	-2.584	.027	.011	3	1
UCEC	Src_pY527 →	-0.470	-2.990	.019	.036	3	1
UCEC	4E-BP1 →	+0.275	+2.199	.029	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

EGFR_pY1068 by SLC25A28 expression — UCEC

Explore this box plot interactively →