SLC25A25

Across TCGA pan-cancer cohorts, SLC25A25 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SLC25A25 data layer compared with 19 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher SLC25A25 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated SLC25A25 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LSCC show a favorable association.

CCRCC, PDAC, and LSCC are the cancer types where SLC25A25 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Tertile	III,IV	1.000	0.728	.009	20	view →
PDAC	DFS	Median	III,IV	0.371	0.998	.010	9	view →
LSCC	DFS	Quartile	II,III,IV	0.933	0.582	.018	7	view →
GBM	OS	Median	All	0.886	0.746	.022	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SLC25A25–CCRCC (OS)

Open the CCRCC breakdown →