SLC25A25

Across TCGA patient cohorts, SLC25A25 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC25A25-associated genes across cancer lineages are ATM, mTOR_pS2448, and Notch1. Each is linked with SLC25A25 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC25A25-to-partner and partner-to-SLC25A25 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by SLC25A25-low versus SLC25A25-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC25A25→partner) and Y-score (partner→SLC25A25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.443	-1.584	.012	.036	3	3
UCEC	mTOR_pS2448 →	-0.153	-2.202	.008	.010	3	2
UCEC	Notch1 →	+0.187	+2.128	<.001	.009	3	2
UCEC	p62 Lck ligand →	+0.430	+2.817	<.001	.001	3	2
UCEC	EGFR_pY1068 →	-0.233	-2.700	.017	.006	3	1
UCEC	EGFR →	-0.190	-1.584	.002	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

ATM by SLC25A25 expression — UCEC

Explore this box plot interactively →