SLC25A24

Across TCGA pan-cancer cohorts, SLC25A24 mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of SLC25A24’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where SLC25A24 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types SLC25A24 is over-expressed in tumor, although a few such as LSCC and LUAD show the opposite, repressed pattern.

LSCC, LUAD, and PDAC are the cancer types where SLC25A24 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SLC25A24 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Male	II,III,IV	−0.697	<.001	9	view →
LUAD	Male	III,IV	−0.651	<.001	8	view →
PDAC	Female	II,III,IV	+0.643	<.001	8	view →
CCRCC	Male	III,IV	+0.262	<.001	6	view →
HNSC	All	II,III,IV	+0.159	.002	6	view →
COAD	All	II,III,IV	+0.115	.011	3	view →
OV	All	All	−0.591	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

SLC25A24–LSCC

Open the LSCC breakdown →