SLC25A23

Across TCGA pan-cancer cohorts, SLC25A23 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of SLC25A23’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SLC25A23 RNA is repressed in tumor relative to normal tissue. In most cancer types SLC25A23 is over-expressed in tumor, although a few such as HNSC and BLCA show the opposite, repressed pattern.

HNSC, BLCA, and COAD are the cancer types where SLC25A23 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SLC25A23 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	IV	−1.283	<.001	12	view →
BLCA	Male	IV	−3.727	<.001	11	view →
COAD	Female	All	−1.530	<.001	11	view →
THCA	Male	III,IV	−1.058	<.001	11	view →
READ	Female	All	−2.146	<.001	7	view →
LIHC	Female	II,III,IV	+1.080	<.001	7	view →
UCEC	All	All	−0.998	<.001	6	view →
KIRP	All	II,III,IV	+0.586	.006	6	view →
LUAD	Male	All	−0.681	<.001	5	view →
LUSC	All	All	−0.645	<.001	5	view →
CHOL	All	All	+1.513	<.001	3	view →
STAD	All	All	−0.594	.017	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

SLC25A23–HNSC

Open the HNSC breakdown →