SLC25A22

Across TCGA pan-cancer cohorts, SLC25A22 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated SLC25A22 data layer compared with 29 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher SLC25A22 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SLC25A22 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

CCRCC, HNSC, and LUAD are the cancer types where SLC25A22 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	III,IV	0.460	0.885	.002	35	view →
HNSC	DFS	Median	All	0.759	0.518	.001	23	view →
LUAD	DFS	Tertile	II,III,IV	0.946	0.775	.002	15	view →
PDAC	OS	Tertile	II,III,IV	0.379	0.654	.014	13	view →
LSCC	OS	Median	All	1.000	0.936	.010	8	view →
COAD	DFS	Median	IV	0.493	0.944	.031	6	view →
GBM	DFS	Quartile	All	0.833	0.669	.026	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

SLC25A22–CCRCC (DFS)

Open the CCRCC breakdown →