SLC25A22

Across TCGA patient cohorts, SLC25A22 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC25A22-associated genes across cancer lineages are Akt_pS473, Akt_pT308, and GSK-3a-b_pS21_S9. Each is linked with SLC25A22 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC25A22-to-partner and partner-to-SLC25A22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Akt_pS473 grouped by SLC25A22-low versus SLC25A22-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC25A22→partner) and Y-score (partner→SLC25A22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Akt_pS473 →	+0.883	+3.000	.032	.037	3	2
UCEC	Akt_pT308 →	+0.841	+3.000	.020	.036	3	2
UCEC	GSK-3a-b_pS21_S9 →	+0.540	+3.000	.028	.037	3	1
UCEC	Tuberin_pT1462 →	+0.451	+2.817	<.001	.036	3	1
UCEC	Rab11 →	-0.187	-3.000	.026	.037	2	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Akt_pS473 by SLC25A22 expression — UCEC

Explore this box plot interactively →