SLC25A22

Across TCGA cell cohorts, SLC25A22 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,757 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SLC25A22-associated GO terms across cancer lineages are Malate-aspartate shuttle, Transcription initiation at RNA polymerase I promoter, and Transcription pausing by RNA polymerase II. Each is linked with SLC25A22 in more than 16 cancer types. Because this analysis shows association rather than direction, both SLC25A22-to-partner and partner-to-SLC25A22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Malate-aspartate shuttle grouped by SLC25A22-low versus SLC25A22-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC25A22→partner) and Y-score (partner→SLC25A22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Malate-aspartate shuttle →	+0.162	+0.930	<.001	.001	3	17
BONE	Transcription initiation at RNA polymerase I promoter →	+0.132	+1.030	.001	.002	3	15
BONE	Transcription pausing by RNA polymerase II →	+0.184	+1.186	<.001	<.001	3	14
URINARY_TRACT	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.148	+1.225	.005	<.001	3	14
STOMACH	Transcription by RNA polymerase III →	+0.081	+1.329	<.001	<.001	3	14
PANCREAS	Telomere tethering at nuclear periphery →	+0.131	+1.203	<.001	.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,757 associations by consensus.

Malate-aspartate shuttle by SLC25A22 expression — LUNG_SCLC

Explore this box plot interactively →