SLC25A21

Across TCGA patient cohorts, SLC25A21 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC25A21-associated genes across cancer lineages are FOXO3a, Caspase-7-cleavedD198, and Chk2. Each is linked with SLC25A21 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC25A21-to-partner and partner-to-SLC25A21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a grouped by SLC25A21-low versus SLC25A21-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC25A21→partner) and Y-score (partner→SLC25A21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	FOXO3a →	-0.164	-3.000	.008	.034	3	2
UCEC	Caspase-7-cleavedD198 →	+1.111	+3.584	<.001	.002	3	2
SKCM	Chk2 →	-0.265	-3.169	.030	.019	3	1
UCEC	EGFR_pY1068 →	-0.272	-3.584	.024	.002	3	1
UCEC	VHL →	-0.923	-3.321	.004	.010	3	1
UCEC	c-Jun_pS73 →	-0.163	-2.986	.033	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

FOXO3a by SLC25A21 expression — SKCM

Explore this box plot interactively →