SLC25A19

Across TCGA patient cohorts, SLC25A19 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC25A19-associated genes across cancer lineages are EGFR_pY1068, A-Raf_pS299, and ERK2. Each is linked with SLC25A19 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC25A19-to-partner and partner-to-SLC25A19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by SLC25A19-low versus SLC25A19-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC25A19→partner) and Y-score (partner→SLC25A19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.260	-3.321	.014	.010	3	1
UCEC	A-Raf_pS299 →	-0.139	-2.321	.006	.034	3	1
UCEC	ERK2 →	+0.267	+3.321	.001	.009	3	1
UCEC	Fibronectin →	-0.289	-1.700	.039	.044	3	1
UCEC	JNK_pT183_Y185 →	-0.192	-2.321	.007	.033	3	1
UCEC	JNK2 →	+0.269	+2.222	.001	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

EGFR_pY1068 by SLC25A19 expression — UCEC

Explore this box plot interactively →