SLC25A18

Across TCGA patient cohorts, SLC25A18 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC25A18-associated genes across cancer lineages are eIF4E, TAZ, and Tuberin. Each is linked with SLC25A18 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC25A18-to-partner and partner-to-SLC25A18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by SLC25A18-low versus SLC25A18-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC25A18→partner) and Y-score (partner→SLC25A18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.240	+3.000	.030	.036	2	2
UCEC	TAZ →	-0.153	-2.990	.039	.036	3	1
UCEC	Tuberin →	+0.409	+3.321	.003	.010	3	1
UCEC	Caspase-8 →	-0.285	-3.143	.030	.018	3	1
UCEC	Cyclin-B1 →	+0.808	+3.321	.005	.010	3	1
UCEC	VHL →	-1.645	-3.321	<.001	.010	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

eIF4E by SLC25A18 expression — UCEC

Explore this box plot interactively →