SLC25A16

Across TCGA pan-cancer cohorts, SLC25A16 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated SLC25A16 data layer compared with 23 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SLC25A16 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SLC25A16 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

HNSC, UCEC, and CCRCC are the cancer types where SLC25A16 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.901	0.445	<.001	48	view →
UCEC	OS	Median	III,IV	0.510	1.000	.037	4	view →
CCRCC	DFS	Median	All	0.960	0.870	.034	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

SLC25A16–HNSC (DFS)

Open the HNSC breakdown →