SLC25A16

Across TCGA patient cohorts, SLC25A16 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC25A16-associated genes across cancer lineages are JNK_pT183_Y185, Ku80, and MEK1. Each is linked with SLC25A16 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC25A16-to-partner and partner-to-SLC25A16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by SLC25A16-low versus SLC25A16-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC25A16→partner) and Y-score (partner→SLC25A16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.180	-2.308	.033	.036	3	1
UCEC	Ku80 →	+0.273	+2.335	.021	.020	3	1
UCEC	MEK1 →	+0.529	+3.459	.003	.005	3	1
UCEC	STAT3_pY705 →	-0.566	-3.459	<.001	.005	3	1
UCEC	Tuberin →	+0.434	+3.459	.001	.005	3	1
UCEC	ATM →	-0.626	-2.321	.005	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

JNK_pT183_Y185 by SLC25A16 expression — UCEC

Explore this box plot interactively →