SLC25A11

Across TCGA pan-cancer cohorts, SLC25A11 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SLC25A11 data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher SLC25A11 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SLC25A11 expression acts as an unfavorable survival marker, although some lineages such as GBM and HNSC show a favorable association.

GBM, HNSC, and CCRCC are the cancer types where SLC25A11 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	DFS	Quartile	All	0.942	0.552	<.001	15	view →
HNSC	DFS	Median	III,IV	0.860	0.697	.012	10	view →
CCRCC	DFS	Tertile	All	0.883	0.478	.007	7	view →
PDAC	DFS	Tertile	All	0.321	0.496	.018	7	view →
LSCC	OS	Tertile	III,IV	0.979	0.583	.022	7	view →
UCEC	DFS	Quartile	All	0.815	1.000	.026	6	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

SLC25A11–GBM (DFS)

Open the GBM breakdown →