SLC23A1

Across TCGA patient cohorts, SLC23A1 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC23A1-associated genes across cancer lineages are 4E-BP1, JNK2, and MSH6. Each is linked with SLC23A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC23A1-to-partner and partner-to-SLC23A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by SLC23A1-low versus SLC23A1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC23A1→partner) and Y-score (partner→SLC23A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	4E-BP1 →	+0.288	+2.815	.016	.036	2	2
UCEC	JNK2 →	+0.172	+1.415	.021	.046	3	1
UCEC	MSH6 →	-0.373	-3.584	.002	.002	3	1
UCEC	p70-S6K →	+0.150	+1.792	.038	.008	3	1
UCEC	p90 RSK →	+0.152	+1.778	.034	.008	3	1
UCEC	Rab11 →	-0.118	-2.169	.030	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

4E-BP1 by SLC23A1 expression — COAD

Explore this box plot interactively →