SLC22A7

Across TCGA patient cohorts, SLC22A7 mutation is significantly associated with the RNA expression of many other genes, with 2,696 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC22A7-associated genes across cancer lineages are TYW3, SLBP, and MELK. Each is linked with SLC22A7 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC22A7-to-partner and partner-to-SLC22A7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TYW3 grouped by SLC22A7-low versus SLC22A7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC22A7→partner) and Y-score (partner→SLC22A7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TYW3 →	+0.443	+1.960	<.001	<.001	3	3
UCEC	SLBP →	+0.556	+2.273	<.001	<.001	3	3
UCEC	MELK →	+0.688	+3.010	.001	<.001	3	3
UCEC	LSM3 →	+0.401	+2.617	.007	<.001	3	3
SKCM	SPATA5L1 →	+0.507	+2.604	.003	.005	3	3
SKCM	ZWILCH →	+0.648	+3.636	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,696 associations by consensus.

TYW3 by SLC22A7 expression — UCEC

Explore this box plot interactively →