SLC22A7

Across TCGA cell cohorts, SLC22A7 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC22A7-associated genes across cancer lineages are NPVF, GSX1, and CRYGB. Each is linked with SLC22A7 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC22A7-to-partner and partner-to-SLC22A7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NPVF grouped by SLC22A7-low versus SLC22A7-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC22A7→partner) and Y-score (partner→SLC22A7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	NPVF →	+0.129	+4.754	<.001	.005	3	1
CNS	GSX1 →	+0.010	+5.357	<.001	.001	3	1
CNS	CRYGB →	+0.164	+4.754	<.001	.005	3	1
SKIN	CR1 →	+0.031	+3.793	<.001	.007	3	1
LARGE_INTESTINE	BRDT →	+0.145	+3.906	<.001	.002	3	1
LARGE_INTESTINE	OR1L6 →	+0.018	+4.022	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

NPVF by SLC22A7 expression — CNS

Explore this box plot interactively →