Across TCGA patient cohorts, SLC22A6 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC22A6-associated genes across cancer lineages are PDCD4, Rab25, and Annexin-1. Each is linked with SLC22A6 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC22A6-to-partner and partner-to-SLC22A6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC22A6→partner) and Y-score (partner→SLC22A6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.714	-2.415	<.001	.003	2	3
UCEC	Rab25 →	-0.400	-2.999	.002	.035	3	2
UCEC	Annexin-1 →	+0.572	+3.321	.006	.009	3	2
UCEC	ATM →	-0.615	-1.906	<.001	.016	3	2
SKCM	Acetyl-a-Tubulin-Lys40 →	+0.613	+2.321	.006	.006	3	2
UCEC	EGFR_pY1068 →	-0.212	-1.906	.036	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

Exploration

SLC22A6 survival (RNA) · tumor vs normal (RNA) · all SLC22A6 data types