Across TCGA patient cohorts, SLC22A5 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC22A5-associated genes across cancer lineages are ASNS, 14-3-3_beta, and EGFR_pY1068. Each is linked with SLC22A5 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC22A5-to-partner and partner-to-SLC22A5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC22A5→partner) and Y-score (partner→SLC22A5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.321	+2.999	.036	.035	3	2
UCEC	14-3-3_beta →	-0.123	-3.295	.003	.009	3	1
UCEC	EGFR_pY1068 →	-0.298	-2.222	.005	.011	3	1
UCEC	A-Raf_pS299 →	-0.159	-2.584	.001	.010	3	1
UCEC	FoxM1 →	+0.218	+1.700	.047	.044	3	1
UCEC	MEK1 →	+0.452	+2.115	.003	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

Exploration

SLC22A5 survival (RNA) · tumor vs normal (RNA) · all SLC22A5 data types