Across TCGA cell cohorts, SLC22A5 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC22A5-associated genes across cancer lineages are MAGEB4, OBP2A, and KLHDC7B. Each is linked with SLC22A5 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC22A5-to-partner and partner-to-SLC22A5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC22A5→partner) and Y-score (partner→SLC22A5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MAGEB4 →	+0.014	+4.000	<.001	<.001	3	1
LARGE_INTESTINE	OBP2A →	+0.110	+2.878	<.001	.009	3	1
LARGE_INTESTINE	KLHDC7B →	+0.903	+3.485	<.001	.004	3	1
LARGE_INTESTINE	CCDC54 →	+0.119	+3.736	.001	.004	3	1
LARGE_INTESTINE	SPINK9 →	+0.243	+3.115	<.001	.004	3	1
SKIN	LIM2 →	+0.035	+3.930	.006	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Exploration

SLC22A5 survival (RNA) · tumor vs normal (RNA) · all SLC22A5 data types