Across TCGA patient cohorts, SLC22A4 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC22A4-associated genes across cancer lineages are 14-3-3_beta, eIF4E, and FOXO3a_pS318_S321. Each is linked with SLC22A4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC22A4-to-partner and partner-to-SLC22A4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC22A4→partner) and Y-score (partner→SLC22A4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.112	-3.295	.004	.009	3	1
UCEC	eIF4E →	+0.229	+2.502	.005	.002	3	1
UCEC	FOXO3a_pS318_S321 →	-0.120	-2.312	.014	.005	3	1
UCEC	ACC1 →	+0.341	+3.183	.016	.009	3	1
UCEC	JNK2 →	+0.185	+1.584	.017	.036	3	1
UCEC	Ku80 →	+0.220	+2.009	.017	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Exploration

SLC22A4 survival (RNA) · tumor vs normal (RNA) · all SLC22A4 data types