Across TCGA cell cohorts, SLC22A4 mutation is significantly associated with the RNA expression of many other genes, with 74 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC22A4-associated genes across cancer lineages are F9, MS4A2, and PRAMEF10. Each is linked with SLC22A4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC22A4-to-partner and partner-to-SLC22A4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC22A4→partner) and Y-score (partner→SLC22A4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	F9 →	+0.016	+4.321	.002	.009	3	2
CNS	MS4A2 →	+0.034	+4.169	<.001	.008	3	1
CNS	PRAMEF10 →	+0.289	+4.754	<.001	.005	3	1
CNS	PRAMEF33 →	+0.432	+4.321	<.001	.009	3	1
BLOOD_Lymphoma	CABP5 →	+0.016	+4.867	<.001	.009	3	1
LARGE_INTESTINE	ZBED4 →	+0.612	+3.137	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 74 associations by consensus.

Exploration

SLC22A4 survival (RNA) · tumor vs normal (RNA) · all SLC22A4 data types