SLC22A3

Across TCGA pan-cancer cohorts, SLC22A3 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated SLC22A3 data layer compared with 25 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SLC22A3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SLC22A3 expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

HNSC and LUAD are the cancer types where SLC22A3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	IV	0.490	0.889	.017	10	view →
LUAD	OS	Tertile	II,III,IV	1.000	0.331	.014	10	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

SLC22A3–HNSC (DFS)

Open the HNSC breakdown →