SLC22A3

Across TCGA patient cohorts, SLC22A3 mutation is significantly associated with the RNA expression of many other genes, with 3,001 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC22A3-associated genes across cancer lineages are RAB8A, CCL4, and CCL4L2. Each is linked with SLC22A3 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC22A3-to-partner and partner-to-SLC22A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RAB8A grouped by SLC22A3-low versus SLC22A3-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC22A3→partner) and Y-score (partner→SLC22A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RAB8A →	+0.301	+2.945	.006	<.001	3	3
UCEC	CCL4 →	+0.937	+2.258	<.001	<.001	3	3
UCEC	CCL4L2 →	+0.686	+1.398	<.001	.004	3	3
COAD	PPCDC →	+0.422	+3.375	.003	.005	3	3
COAD	PXMP2 →	+0.489	+3.335	.006	.005	3	3
STAD	RNU2-47P →	+0.315	+3.951	.006	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,001 associations by consensus.

RAB8A by SLC22A3 expression — SKCM

Explore this box plot interactively →