SLC22A3

Across TCGA patient cohorts, SLC22A3 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC22A3-associated genes across cancer lineages are PDCD4, eIF4E, and GAPDH. Each is linked with SLC22A3 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC22A3-to-partner and partner-to-SLC22A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by SLC22A3-low versus SLC22A3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC22A3→partner) and Y-score (partner→SLC22A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.519	-2.169	<.001	.002	3	3
UCEC	eIF4E →	+0.227	+2.273	<.001	<.001	3	2
COAD	GAPDH →	+0.807	+3.008	.002	.019	3	2
UCEC	JNK_pT183_Y185 →	-0.114	-1.308	.024	.012	3	2
UCEC	p21 →	+0.115	+1.502	.046	.027	3	2
UCEC	Rictor_pT1135 →	-0.084	-1.415	.006	.040	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

PDCD4 by SLC22A3 expression — UCEC

Explore this box plot interactively →