SLC22A3

Across TCGA cell cohorts, SLC22A3 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,522 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible SLC22A3-associated GO terms across cancer lineages are Regulation of anoikis, Plasma membrane organization, and Symbiont entry into host. Each is linked with SLC22A3 in more than 8 cancer types. Because this analysis shows association rather than direction, both SLC22A3-to-partner and partner-to-SLC22A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of anoikis grouped by SLC22A3-low versus SLC22A3-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC22A3→partner) and Y-score (partner→SLC22A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Regulation of anoikis →	+0.085	+0.620	.002	.007	3	9
KIDNEY	Plasma membrane organization →	+0.111	+2.755	.001	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	Symbiont entry into host →	+0.105	+1.120	.001	.009	3	8
UPPER_AERODIGESTIVE_TRACT	Symbiont entry into host cell →	+0.105	+1.120	.001	.009	3	8
UPPER_AERODIGESTIVE_TRACT	Biological process involved in interaction with host →	+0.097	+1.299	.001	.003	3	8
LUNG_NSCLC_LUAD	Zymogen activation →	+0.143	+1.234	<.001	.003	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,522 associations by consensus.

Regulation of anoikis by SLC22A3 expression — SOFT_TISSUE

Explore this box plot interactively →