SLC22A3

Across TCGA cell cohorts, SLC22A3 mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SLC22A3-associated genes across cancer lineages are ODF1, GIP, and GPRC6A. Each is linked with SLC22A3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC22A3-to-partner and partner-to-SLC22A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ODF1 grouped by SLC22A3-low versus SLC22A3-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC22A3→partner) and Y-score (partner→SLC22A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ODF1 →	+0.013	+4.022	<.001	.006	3	1
SKIN	GIP →	+0.072	+3.196	<.001	.007	3	1
SKIN	GPRC6A →	+0.064	+3.974	<.001	.002	3	1
SKIN	OR6C70 →	+0.055	+3.632	<.001	.003	3	1
SKIN	OR4A47 →	+0.010	+4.022	<.001	.006	3	1
SKIN	PRSS58 →	+0.037	+3.977	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

ODF1 by SLC22A3 expression — SKIN

Explore this box plot interactively →