SLC22A3

Across TCGA cell cohorts, SLC22A3 mutation is significantly associated with the mutation status of many other genes, with 1,828 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC22A3-associated genes across cancer lineages are DMXL1, PLCB1, and TACC2. Each is linked with SLC22A3 in more than 3 cancer types. Because this analysis shows association rather than direction, both SLC22A3-to-partner and partner-to-SLC22A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DMXL1 grouped by SLC22A3-low versus SLC22A3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC22A3→partner) and Y-score (partner→SLC22A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	DMXL1 →	+2.582	+3.377	.001	.001	1	4
SOFT_TISSUE	PLCB1 →	+5.066	+4.502	.007	.007	1	4
SOFT_TISSUE	TACC2 →	+5.066	+4.502	.007	.007	1	4
LARGE_INTESTINE	KCNQ1 →	+3.536	+4.129	<.001	<.001	1	3
BLOOD_Leukemia	MYCBP2 →	+2.360	+3.189	.002	.002	1	3
SKIN	PSD →	+3.117	+3.117	.009	.009	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,828 associations by consensus.

DMXL1 by SLC22A3 expression — BLOOD_Leukemia

Explore this box plot interactively →