SLC22A23

Across TCGA patient cohorts, SLC22A23 mutation is significantly associated with the RNA expression of many other genes, with 2,526 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC22A23-associated genes across cancer lineages are BAG3, DPEP1, and PKN3. Each is linked with SLC22A23 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC22A23-to-partner and partner-to-SLC22A23 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BAG3 grouped by SLC22A23-low versus SLC22A23-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC22A23→partner) and Y-score (partner→SLC22A23) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BAG3 →	+0.620	+2.456	<.001	<.001	3	2
UCEC	DPEP1 →	-1.003	-2.502	<.001	<.001	3	2
UCEC	PKN3 →	+0.649	+1.595	<.001	<.001	3	2
UCEC	ANKRD23 →	-0.269	-1.773	<.001	<.001	3	2
UCEC	SNRPD1 →	+0.360	+2.010	.001	<.001	3	2
UCEC	REEP4 →	+0.364	+2.010	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,526 associations by consensus.

BAG3 by SLC22A23 expression — UCEC

Explore this box plot interactively →