SLC22A23

Across TCGA patient cohorts, SLC22A23 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC22A23-associated genes across cancer lineages are mTOR_pS2448, Notch1, and PDCD4. Each is linked with SLC22A23 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC22A23-to-partner and partner-to-SLC22A23 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by SLC22A23-low versus SLC22A23-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC22A23→partner) and Y-score (partner→SLC22A23) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.113	-2.074	.012	.004	3	2
UCEC	Notch1 →	+0.112	+1.321	.008	.012	3	2
UCEC	PDCD4 →	-0.425	-1.125	.002	.033	3	2
UCEC	ASNS →	+0.247	+1.362	.023	.034	3	2
UCEC	4E-BP1_pT70 →	+0.079	+1.125	.022	.033	3	2
UCEC	4E-BP1 →	+0.254	+1.795	.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

mTOR_pS2448 by SLC22A23 expression — UCEC

Explore this box plot interactively →