SLC22A2

Across TCGA pan-cancer cohorts, SLC22A2 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SLC22A2 data layer compared with 20 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher SLC22A2 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SLC22A2 expression acts as an unfavorable survival marker, although some lineages such as LUSC and SKCM show a favorable association.

BRCA, PRAD, and UCEC are the cancer types where SLC22A2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Median	II,III,IV	0.165	0.913	<.001	36	view →
PRAD	DFS	Median	All	0.617	0.886	.013	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
LUSC	DFS	Median	All	0.858	0.383	.036	2	view →
SKCM	DFS	Median	II,III,IV	0.835	0.662	.027	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SLC22A2–BRCA (OS)

Open the BRCA breakdown →