SLC22A2

Across TCGA patient cohorts, SLC22A2 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC22A2-associated genes across cancer lineages are TFRC, 14-3-3_beta, and FoxM1. Each is linked with SLC22A2 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC22A2-to-partner and partner-to-SLC22A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by SLC22A2-low versus SLC22A2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC22A2→partner) and Y-score (partner→SLC22A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.640	+2.807	<.001	.002	3	3
UCEC	14-3-3_beta →	-0.103	-2.295	.001	.005	3	2
UCEC	FoxM1 →	+0.177	+1.652	.038	.006	3	2
UCEC	Ku80 →	+0.205	+1.405	.008	.012	3	2
UCEC	PR →	-0.210	-3.459	.011	.005	3	2
UCEC	Caspase-7-cleavedD198 →	+0.819	+3.087	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

TFRC by SLC22A2 expression — UCEC

Explore this box plot interactively →