SLC22A2

Across TCGA cell cohorts, SLC22A2 mutation is significantly associated with the RNA expression of many other genes, with 224 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC22A2-associated genes across cancer lineages are MAGEB18, OR13C2, and PHF7. Each is linked with SLC22A2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC22A2-to-partner and partner-to-SLC22A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB18 grouped by SLC22A2-low versus SLC22A2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC22A2→partner) and Y-score (partner→SLC22A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MAGEB18 →	+0.096	+4.567	<.001	.001	3	2
SKIN	OR13C2 →	+0.022	+4.437	<.001	.004	3	1
LARGE_INTESTINE	PHF7 →	+0.883	+3.299	<.001	.004	3	1
LARGE_INTESTINE	CRACD →	+1.000	+3.212	.005	.006	3	1
LARGE_INTESTINE	SYF2 →	+0.570	+3.212	<.001	.006	3	1
LARGE_INTESTINE	CCND2 →	+2.507	+3.212	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 224 associations by consensus.

MAGEB18 by SLC22A2 expression — BLOOD_Leukemia

Explore this box plot interactively →