SLC22A18

Across TCGA patient cohorts, SLC22A18 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC22A18-associated genes across cancer lineages are EGFR, A-Raf_pS299, and JNK2. Each is linked with SLC22A18 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC22A18-to-partner and partner-to-SLC22A18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR grouped by SLC22A18-low versus SLC22A18-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC22A18→partner) and Y-score (partner→SLC22A18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR →	-0.228	-3.321	<.001	.010	3	1
UCEC	A-Raf_pS299 →	-0.148	-2.459	.002	.019	3	1
UCEC	JNK2 →	+0.240	+2.196	.002	.032	3	1
UCEC	Ku80 →	+0.187	+1.498	.049	.036	3	1
UCEC	MEK1 →	+0.370	+2.000	.011	.030	3	1
UCEC	mTOR_pS2448 →	-0.164	-2.415	.006	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

EGFR by SLC22A18 expression — UCEC

Explore this box plot interactively →