SLC22A18

Across TCGA cell cohorts, SLC22A18 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,835 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SLC22A18-associated GO terms across cancer lineages are Regulation of protein localization to cell periphery, Cilium movement involved in cell motility, and Meiotic sister chromatid cohesion. Each is linked with SLC22A18 in more than 14 cancer types. Because this analysis shows association rather than direction, both SLC22A18-to-partner and partner-to-SLC22A18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of protein localization to cell periphery grouped by SLC22A18-low versus SLC22A18-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC22A18→partner) and Y-score (partner→SLC22A18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of protein localization to cell periphery →	+0.095	+1.660	<.001	<.001	3	15
URINARY_TRACT	Cilium movement involved in cell motility →	-0.115	-1.340	<.001	.002	3	14
STOMACH	Meiotic sister chromatid cohesion →	-0.189	-2.255	<.001	<.001	3	14
BONE	DNA replication initiation →	-0.179	-1.286	.001	.001	3	14
OESOPHAGUS	Positive regulation of chromosome condensation →	-0.227	-1.868	.001	<.001	3	14
STOMACH	Positive regulation of protein localization to plasma membrane →	+0.150	+2.115	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,835 associations by consensus.

Regulation of protein localization to cell periphery by SLC22A18 expression — BONE

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