SLC22A17

Across TCGA patient cohorts, SLC22A17 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC22A17-associated genes across cancer lineages are Annexin-1, EGFR_pY1068, and EGFR. Each is linked with SLC22A17 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC22A17-to-partner and partner-to-SLC22A17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by SLC22A17-low versus SLC22A17-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC22A17→partner) and Y-score (partner→SLC22A17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.941	+3.341	<.001	.005	3	3
UCEC	EGFR_pY1068 →	-0.262	-2.000	.020	.032	3	2
UCEC	EGFR →	-0.203	-3.143	.004	.018	3	2
UCEC	mTOR_pS2448 →	-0.165	-2.000	.014	.032	3	2
UCEC	PDCD4 →	-0.692	-3.160	.001	.019	3	2
UCEC	eIF4E →	+0.255	+3.459	.007	.005	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

Annexin-1 by SLC22A17 expression — UCEC

Explore this box plot interactively →