SLC22A13

Across TCGA patient cohorts, SLC22A13 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC22A13-associated genes across cancer lineages are EGFR, GSK-3a-b_pS21_S9, and INPP4B. Each is linked with SLC22A13 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC22A13-to-partner and partner-to-SLC22A13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR grouped by SLC22A13-low versus SLC22A13-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC22A13→partner) and Y-score (partner→SLC22A13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR →	-0.201	-1.700	.003	.044	3	1
UCEC	GSK-3a-b_pS21_S9 →	+0.408	+3.169	.024	.018	3	1
UCEC	INPP4B →	-0.308	-2.459	.024	.019	3	1
UCEC	Lck →	+0.173	+1.700	.042	.044	3	1
UCEC	Myosin-IIa →	+0.249	+3.180	.002	.010	3	1
UCEC	Notch1 →	+0.155	+2.335	.009	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

EGFR by SLC22A13 expression — UCEC

Explore this box plot interactively →