Across TCGA patient cohorts, SLC22A12 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC22A12-associated genes across cancer lineages are Caspase-7-cleavedD198, Bap1-c-4, and p70-S6K. Each is linked with SLC22A12 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC22A12-to-partner and partner-to-SLC22A12 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC22A12→partner) and Y-score (partner→SLC22A12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.845	+2.189	.002	.034	3	3
LUAD	Bap1-c-4 →	+0.302	+3.186	.002	.010	3	2
UCEC	p70-S6K →	+0.197	+2.611	.028	.006	3	2
UCEC	S6_pS240_S244 →	+0.465	+3.169	.014	.019	3	2
LUAD	AMPK_alpha →	-0.183	-3.169	.030	.019	3	1
LUAD	S6 →	+0.354	+3.203	.014	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

Exploration

SLC22A12 survival (RNA) · tumor vs normal (RNA) · all SLC22A12 data types