SLC22A11

Across TCGA patient cohorts, SLC22A11 mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC22A11-associated genes across cancer lineages are Acetyl-a-Tubulin-Lys40, Ku80, and mTOR_pS2448. Each is linked with SLC22A11 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC22A11-to-partner and partner-to-SLC22A11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Acetyl-a-Tubulin-Lys40 grouped by SLC22A11-low versus SLC22A11-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC22A11→partner) and Y-score (partner→SLC22A11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Acetyl-a-Tubulin-Lys40 →	+0.778	+3.000	.004	.035	3	2
SKCM	Ku80 →	+0.332	+2.321	.015	.035	3	2
UCEC	mTOR_pS2448 →	-0.135	-2.439	.020	.019	3	2
UCEC	Notch1 →	+0.161	+1.598	.003	.040	3	2
UCEC	Rad50 →	-0.226	-1.584	.017	.036	3	2
UCEC	Annexin-1 →	+0.539	+1.894	.009	.030	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

Acetyl-a-Tubulin-Lys40 by SLC22A11 expression — SKCM

Explore this box plot interactively →