SLC22A11

Across TCGA cell cohorts, SLC22A11 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,281 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SLC22A11-associated GO terms across cancer lineages are Regulation of bile acid secretion, Cyclic purine nucleotide metabolic process, and Regulation of transcription initiation by RNA polymerase II. Each is linked with SLC22A11 in more than 5 cancer types. Because this analysis shows association rather than direction, both SLC22A11-to-partner and partner-to-SLC22A11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of bile acid secretion grouped by SLC22A11-low versus SLC22A11-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC22A11→partner) and Y-score (partner→SLC22A11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Regulation of bile acid secretion →	+1.939	+0.078	<.001	.006	3	6
BREAST	Cyclic purine nucleotide metabolic process →	-0.065	-0.016	.004	.002	3	5
UPPER_AERODIGESTIVE_TRACT	Regulation of transcription initiation by RNA polymerase II →	+0.059	+0.128	<.001	.001	3	5
BLOOD_Myeloma	Endoplasmic reticulum unfolded protein response →	+0.103	+0.056	<.001	.002	2	6
BLOOD_Leukemia	Positive regulation of membrane depolarization →	+0.101	+0.165	<.001	.009	3	5
OESOPHAGUS	Regulation of ketone biosynthetic process →	+0.104	+0.218	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,281 associations by consensus.

Regulation of bile acid secretion by SLC22A11 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →