SLC22A11

Across TCGA cell cohorts, SLC22A11 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC22A11-associated genes across cancer lineages are C1QTNF7, TBC1D21, and WDR87. Each is linked with SLC22A11 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC22A11-to-partner and partner-to-SLC22A11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C1QTNF7 grouped by SLC22A11-low versus SLC22A11-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC22A11→partner) and Y-score (partner→SLC22A11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C1QTNF7 →	+0.115	+3.523	<.001	.002	3	1
LARGE_INTESTINE	TBC1D21 →	+0.008	+3.700	<.001	.009	3	1
LARGE_INTESTINE	WDR87 →	+0.020	+3.353	<.001	.004	3	1
LARGE_INTESTINE	OR6Q1 →	+0.012	+3.700	<.001	.009	3	1
BLOOD_Leukemia	IQCF5 →	+0.124	+5.201	<.001	.006	3	1
BREAST	OR2T5 →	+0.025	+4.781	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

C1QTNF7 by SLC22A11 expression — LARGE_INTESTINE

Explore this box plot interactively →