SLC1A6

Across TCGA patient cohorts, SLC1A6 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible SLC1A6-associated genes across cancer lineages are Caspase-7-cleavedD198, ERK2, and MSH2. Each is linked with SLC1A6 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC1A6-to-partner and partner-to-SLC1A6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by SLC1A6-low versus SLC1A6-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC1A6→partner) and Y-score (partner→SLC1A6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.228	+3.016	<.001	.018	3	3
UCEC	ERK2 →	+0.179	+1.584	.018	.036	3	2
UCEC	MSH2 →	-0.273	-3.674	.002	.001	3	2
COAD	eEF2 →	+0.391	+3.169	.003	.018	3	2
SKCM	PDCD4 →	-0.258	-1.222	.048	.033	3	2
SKCM	PTEN →	-0.378	-1.459	.002	.011	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Caspase-7-cleavedD198 by SLC1A6 expression — COAD

Explore this box plot interactively →