SLC1A5

Across TCGA pan-cancer cohorts, SLC1A5 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SLC1A5 data layer compared with 26 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher SLC1A5 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated SLC1A5 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

CESC, SKCM, and LUSC are the cancer types where SLC1A5 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Median	II,III,IV	0.222	0.711	.013	18	view →
SKCM	OS	Median	All	0.249	0.781	.011	12	view →
LUSC	OS	Median	All	0.196	0.724	.049	6	view →
COAD	DFS	Median	All	0.222	0.691	.013	6	view →
UCEC	OS	Median	All	1.000	0.657	.037	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SLC1A5–CESC (DFS)

Open the CESC breakdown →